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Frequently Asked Questions

Ovarian Cysts & Adhesions

What are ovarian cysts?

Ovarian cysts are fluid-filled growths in or on the ovaries.

Why are ovarian cysts painful?

Damage from collapsed or recurrent cysts can cause fibrin-based adhesions to build up. This scarring can cause the ovaries to be attached to surrounding tissue resulting in pain. Some large cysts can also cause displacement of the reproductive organs.

What causes ovarian cysts?

Ovarian cysts can be caused or exacerbated by: irregular menstrual cycles, hormonal imbalance, hypothyroidism, smoking, early menstruation, excess body weight, and several prescription medications.

What types of ovarian cysts are there?

The most common ovarian cyst is the functional cyst which forms when a follicle is given the signal to grow in preparation for ovulation. If this follical fails to rupture and release the egg, it forms a follicular cyst. If the egg is released but the follicle reseals and accumulates fluid it grows into a corpus luteum cyst. Non-functional cysts include chocolate cysts (a blood-filled cyst resulting from endometriosis) and cystadenomas (developed from ovarian tissue).

How are ovarian cysts diagnosed

Ovarian cysts may be determined by imaging - via endovaginal ultrasound, CT, or MRI - or through laparoscopic surgery where small incisions are made, a scope is inserted, and the surgeon can identify, biopsy, or remove the cyst.

Why do I need to urinate so frequently?

Ovarian cysts and the associated fibrin-based adhesions can impinge on bladder capacity depending on their size and position.

Why do I feel bloated?

This may be due to fluid leaking from the cysts and/or pelvic inflammation as a result of the cysts.

Could ovarian cysts be causing my backaches?

Yes. Backaches are a common complaint of women who suffer with ovarian cysts.

How Endovan Works

What is Endovan?

Endovan is an all-natural and hormone-free capsule formulated to quickly and safely increase the body's inherent fibrinolytic activity to help degrade excess fibrin that is the primary cause of adverse symptoms in women with fibroids, ovarian cysts, endometriosis, and fibrocystic disease.

How does Endovan work?

Endovan works by boosting your body's ability to degrade excess fibrin buildup.

Using Endovan

How much should I take?

Take one capsule two times per day with 8 ounces of water. While it's not necessary that Endovan be taken with food, it is often easiest to time the doses in that manner.

How soon will I notice results?

Results will depend on the severity of symptoms but most women notice improvement in the first one to two months with continued progress in subsequent months.

How long will I need to take Endovan?

Some women take Endovan for a few months at a time as symptoms occur and some women stay on it continually. If your body is prone to making excess fibrin then the unfortunate reality is that it may need ongoing management.

What to expect on Endovan

How can I tell if Endovan is working?

The simplest way to tell whether Endovan is working is to track the frequency and severity of your symptoms and note the difference while on Endovan.

Will I feel uncomfortable?

Some women with fibroids, ovarian cysts, and/or endometriosis report mild cramping initially. In addition, you may feel a little extra swelling in the affected area(s). This is normal and will resolve as your body works to rid your system of the excess fibrin. You may skip a dose at any time if these temporary effects become bothersome.

Where does the fibrin go?

As your body degrades abnormal fibrin it is processed by the body as waste and is naturally expelled in the urine and with the normal menstrual flow.

Will I notice any change in my urine?

Maybe. Some women do report a slightly darkened urine when taking Endovan as the body flushes the excess fibrin.

Will my periods by heavier?

Some women do notice a more watery flow during the first cycle or two. This is normal and is a result of your body processing the excess fibrin. You may skip a dose at any time if this temporary effect becomes bothersome.

Will I see any spotting between periods?

You may. Some women do notice a mild spotting during their first couple cycles. This is a transient issue and happens as your abnormal fibrin is broken down and flushed from your system.

Will Endovan shrink my swollen stomach?

If your swollen stomach is due to underlying fibroids, cysts, or endometrial adhesions then you will notice it resolving as your body naturally breaks down the fibrin.

Why do I sometimes feel more swollen in my breasts or abdomen when taking Endovan?

As fibrin is deteriorated by your system you may notice a slight increase in swelling or firmness in the affected area(s). This is temporary and a sign that your immune system is working to degrade the abnormal fibrin.


What are Endovan's ingredients?

Endovan is composed of our patented form of Nattokinase called Nattokinase NSP2™, Cramp Bark (viburnum opulus), Astaxanthin, EGCG Green Tea Extract (decaffeinated), Lycopene, Vitamin B6 (pyridoxine hcl), and Vitamin D3 (cholecalciferol). We adhere to the FDA Good Manufacturing Practices (GMP) which ensure that all of our ingredients meet quality standards and are free from any contamination so you can be confident in their strength and purity.

How do you ensure the quality of ingredients?

Endovan is produced in a facility that adheres to all FDA Dietary Supplement Current Good Manufacturing Practices guidelines.

Is all nattokinase equally effective?

No. Nattokinase can be formulated multiple ways. Our patented Nattokinase NSP2™ is manufactured according to GMP standards and is specially designed to be heat-stable which ensures that it won't break down prematurely.

Do you use GMO ingredients?

No. All Endovan ingredients are non-GMO.

Does Endovan contain soy?

No. Our patented Nattokinase NSP2™ is derived as a byproduct of soy fermentation but contains no soy itself.

Do I need a prescription?

No. Endovan is a natural supplement and is available without a prescription.

How long has Endovan been on the market?

Endovan was introduced by Komodo Naturals in 2004. We now have Endovan customers in over 100 countries and are trusted by thousands of women worldwide.

Safety & Interactions

Is Endovan safe?

Yes. Endovan is all-natural and the individual ingredients are safe

Does Endovan have any side-effects?

During your first cycle or two you may notice slight darkening of urine, minor cramping, more watery flow, and/or an increase in firmness in the abdomen. This is normal and and will resolve as your body works to rid your system of the excess fibrin. You may skip a dose at any time if these temporary effects become bothersome.

Does Endovan interfere with normal clotting?

No. Endovan does not interfere with normal blood clotting in otherwise healthy people. If you have an existing bleeding disorder, please consult your doctor before using Endovan.

Can I use Endovan if I'm anemic?

If you're anemic due to chronic blood loss from especially heavy periods it's best to check with your doctor before taking Endovan.

Will Endovan interfere with the effectiveness of my birth control?

No. Endovan is hormone-free and will not interfere with birth control.

Can I take Endovan with (Progesterone cream / Premarin / Lupron / Depo Provera)?

Yes. Endovan is safe to take with these medications.

Are there any medications, drugs, or supplements that I should not take with Endovan?

Please review with your healthcare provider if you are taking any prescribed anticoagulants. Endovan has no known interactions with any other medications, nutritional supplements, or vitamins.

Endovan & Weight Loss

Why have I gained weight with this condition?

Fibroids, endometriosis, ovarian cysts, and breast lumps all involve some degree of inflammation which - in addition to signalling the production of excess fibrin - causes the body to produce cortisol, a glucocorticoid steroid hormone produced by the adrenal glands. An increase in cortisol production is known to result in increased abdominal fat storage as well as fluid retention.

Will Endovan help me lose this weight?

Endovan isn't for weight loss, but as your body resolves the excess fibrin and the inflammation is reduced, it will naturally cease the call for increased cortisol. With normal cortisol levels you may find it easier to lose weight.


Is Endovan effective for women nearing, in, or past menopause?

Yes, and they may notice results more quickly as the reproductive hormones that contribute to abnormal fibrin growth naturally decline.

What if I'm undergoing hormone therapy?

Since estrogen and progesterone contribute to fibrin growth, you may see slower results than you otherwise would.

Will Endovan work if my periods have become irregular or ceased altogether?

Yes. Endovan will still help your body break down excess fibrin and will be aided by the fact that your reproductive hormones will be moderating.

Will I notice any bleeding or spotting while taking Endovan?

Perhaps. Some women with fibroids and/or endometriosis do report minor spotting for a short time when starting Endovan.

How will I know Endovan is working if I no longer have a period?

Without period-related symptoms, you'll want to watch for improvement in the other areas of common complaint such as swollen or bloated abdomen; pelvic pain and pressure; frequent urination; back pain; and pain during intercourse.


Does Endovan affect fertility?

Fertility can improve if the underlying issue is caused by your fibroids, ovarian cysts, or endometrial adhesions.

Can I take Endovan while trying to conceive?

Endovan has not been studied in pregnancy. If trying to conceive, please discuss with your doctor before using Endovan.

Shipping & Returns

Do you ship to (my country)?

Endovan ships worldwide. At checkout you'll be quoted real-time rates for shipping to your country.

Is Endovan guaranteed?

Absolutely. Endovan is backed by our risk-free 90 day money-back guarantee.

How do I initiate a return?

Simply follow the instructions on our Return Form

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